Semisynthetic Penicillins. I. a-Methylthio-2-chlorocinnamylpenicillin
نویسندگان
چکیده
منابع مشابه
Effect of semisynthetic penicillins on the Limulus lysate test.
Semisynthetic penicillins in concentrations greater than 1.0% (wt/vol) were found to inhibit the limulus lysate assay for endotoxin.
متن کاملComparative in vitro activity of semisynthetic penicillins against Proteeae.
The in vitro susceptibilities of 181 isolates of precisely identified Proteeae species to five semisynthetic penicillins were determined with low and high inocula. Significant differences in susceptibility patterns among various Proteeae species to the penicillins examined were demonstrated. Providencia stuartii was clearly distinguished from Providencia alcalifaciens by its greater resistance ...
متن کاملA New Approach to Semisynthetic Penicillins by the Mixed Anhydride Method
An improvement of the efficiency of organic chemical synthesis was attempted by the imitation of natural reactions. Phosphorylated amino acid derivatives and the rupture of thus obtained »high energy phosphates« was used for aminoacylations of 6-11minopenicillanic acid (6-APA). Namely, the energy-rich mixed anhydrides, formed from adenosine triphosphate (ATP) and amino acids were shown to be th...
متن کاملEarly synergistic interaction between semisynthetic penicillins and aminoglycosidic aminocyclitols against Enterobacteriaceae.
Time-kill curves were used to assess the relative in vitro efficacy of the early interaction of three semisynthetic penicillins with two aminoglycosides against 48 Enterobacteriaceae strains. The most efficacious combinations were piperacillin plus amikacin, which demonstrated synergism (greater than or equal to 2 logs of increased kill after 7 h of incubation) against 43 of 48 (90%) strains, a...
متن کاملIn vitro microbiological evaluation of TEI-1194 and TEI-2012, novel antipseudomonal semisynthetic penicillins.
TEI-1194, sodium 6-[D-(-)-alpha-(coumarin-3-carboxamide)-phenylacetamide] penicillanate and TEI-2012, sodium 6[D-(-)alpha-(8-hydroxy-coumarin-3-carboxamide)-phenylacetamide] penicillanate are new semisynthetic penicillin derivatives both possessing a broad spectrum of in vitro antibacterial activities. Minimal inhibitory concentrations of both agents were compared with carbenicillin. TEI-1194 a...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1965
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.13.1148